Autoinhibitory properties of the parent but not of the N‐oxide metabolite contribute to infusion rate‐dependent voriconazole pharmacokinetics

AIMS: The pharmacokinetics of voriconazole show a nonlinear dose–exposure relationship caused by inhibition of its own CYP3A‐dependent metabolism. Because the magnitude of autoinhibition also depends on voriconazole concentrations, infusion rate might modulate voriconazole exposure. The impact of fo...

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Dettagli Bibliografici
Pubblicato in:Br J Clin Pharmacol
Autori principali: Hohmann, Nicolas, Kreuter, Rebecca, Blank, Antje, Weiss, Johanna, Burhenne, Jürgen, Haefeli, Walter E., Mikus, Gerd
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Pharmacokinetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555860/
https://ncbi.nlm.nih.gov/pubmed/28370390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13297
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