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Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans
AIM: We aimed to establish a method to assess systemic and pre-systemic cytochrome P450 (CYP) 3A activity using ineffective microgram doses of midazolam. METHODS: In an open, one sequence, crossover study, 16 healthy participants received intravenous and oral midazolam at microgram (0.001 mg intrave...
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| Publié dans: | Br J Clin Pharmacol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BlackWell Publishing Ltd
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4309633/ https://ncbi.nlm.nih.gov/pubmed/25588320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12502 |
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