Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans

AIM: We aimed to establish a method to assess systemic and pre-systemic cytochrome P450 (CYP) 3A activity using ineffective microgram doses of midazolam. METHODS: In an open, one sequence, crossover study, 16 healthy participants received intravenous and oral midazolam at microgram (0.001 mg intrave...

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Detaylı Bibliyografya
Yayımlandı:Br J Clin Pharmacol
Asıl Yazarlar: Hohmann, Nicolas, Kocheise, Franziska, Carls, Alexandra, Burhenne, Jürgen, Haefeli, Walter E, Mikus, Gerd
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2015
Konular:
Pharmacokinetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309633/
https://ncbi.nlm.nih.gov/pubmed/25588320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12502
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