Autoinhibitory properties of the parent but not of the N‐oxide metabolite contribute to infusion rate‐dependent voriconazole pharmacokinetics

AIMS: The pharmacokinetics of voriconazole show a nonlinear dose–exposure relationship caused by inhibition of its own CYP3A‐dependent metabolism. Because the magnitude of autoinhibition also depends on voriconazole concentrations, infusion rate might modulate voriconazole exposure. The impact of fo...

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書目詳細資料
發表在:Br J Clin Pharmacol
Main Authors: Hohmann, Nicolas, Kreuter, Rebecca, Blank, Antje, Weiss, Johanna, Burhenne, Jürgen, Haefeli, Walter E., Mikus, Gerd
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2017
主題:
Pharmacokinetics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555860/
https://ncbi.nlm.nih.gov/pubmed/28370390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13297
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