Autoinhibitory properties of the parent but not of the N‐oxide metabolite contribute to infusion rate‐dependent voriconazole pharmacokinetics

AIMS: The pharmacokinetics of voriconazole show a nonlinear dose–exposure relationship caused by inhibition of its own CYP3A‐dependent metabolism. Because the magnitude of autoinhibition also depends on voriconazole concentrations, infusion rate might modulate voriconazole exposure. The impact of fo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Br J Clin Pharmacol
Main Authors: Hohmann, Nicolas, Kreuter, Rebecca, Blank, Antje, Weiss, Johanna, Burhenne, Jürgen, Haefeli, Walter E., Mikus, Gerd
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Pharmacokinetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555860/
https://ncbi.nlm.nih.gov/pubmed/28370390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13297
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