Clarithromycin substantially increases steady-state bosentan exposure in healthy volunteers

AIMS: The aim of this study was to assess the effect of the cytochrome P450 (CYP) 3A4 and organic anion-transporting polypeptide (OATP) 1B1 inhibitor clarithromycin on the pharmacokinetics of bosentan. We also aimed to evaluate the impact of CYP2C9 and SLCO1B1 (encoding for OATP1B1) genotypes and th...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Markert, Christoph, Schweizer, Yvonne, Hellwig, Regina, Wirsching, Theresia, Riedel, Klaus-Dieter, Burhenne, Juergen, Weiss, Johanna, Mikus, Gerd, Haefeli, Walter E
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2014
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895355/
https://ncbi.nlm.nih.gov/pubmed/23738582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12177
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky