Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL

AIMS: Bioavailability of orally administered drugs depends on several factors including active excretion, e.g. by P-glycoprotein (PGP), and presystemic metabolism, e.g. by cytochrome P450 3A (CYP3A), in both gastrointestinal tract and liver. Many drugs including saquinavir are substrates of both PGP...

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Hlavní autoři: Martin-Facklam, Meret, Burhenne, Jürgen, Ding, Reinhard, Fricker, Ruth, Mikus, Gerd, Walter-Sack, Ingeborg, Haefeli, Walter E
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2002
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874336/
https://ncbi.nlm.nih.gov/pubmed/12047481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01595.x
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