Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans

AIMS: The cytochrome P450 enzyme CYP2C9 catalyses the 4′-hydroxylation of the nonsteroidal analgesic drug diclofenac in humans. We studied the influences of the known amino acid variants, CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu), on diclofenac pharmacokinetics after a 50-mg oral dose of diclofe...

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Autores principales: Kirchheiner, Julia, Meineke, Ingolf, Steinbach, Nadine, Meisel, Christian, Roots, Ivar, Brockmöller, Jürgen
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2003
Materias:
Pharmacokinetics/Pharmacodynamics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884192/
https://ncbi.nlm.nih.gov/pubmed/12534640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01712.x
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