Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans

AIMS: The cytochrome P450 enzyme CYP2C9 catalyses the 4′-hydroxylation of the nonsteroidal analgesic drug diclofenac in humans. We studied the influences of the known amino acid variants, CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu), on diclofenac pharmacokinetics after a 50-mg oral dose of diclofe...

詳細記述

保存先:
書誌詳細
主要な著者: Kirchheiner, Julia, Meineke, Ingolf, Steinbach, Nadine, Meisel, Christian, Roots, Ivar, Brockmöller, Jürgen
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Science Inc 2003
主題:
Pharmacokinetics/Pharmacodynamics
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884192/
https://ncbi.nlm.nih.gov/pubmed/12534640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01712.x
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料