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Influence of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir and its active metabolite
AIMS: This study reports the pharmacokinetics of nelfinavir, its active metabolite, M8, and active moiety (nelfinavir + M8) in volunteers genotyped for CYP2C19 as extensive metabolizer (*1*1; n = 38), heterozygous poor metabolizer (PM) (*1*2; n = 22) and homozygous PM (*2*2; n = 6). METHODS: Subject...
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Main Authors: | , , , , , |
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格式: | Artigo |
語言: | Inglês |
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Blackwell Science Inc
2009
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2791974/ https://ncbi.nlm.nih.gov/pubmed/19916992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03499.x |
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