Novel 1-8-bridged chiral quinolones with activity against topoisomerase II: stereospecificity of the eukaryotic enzyme.

A series of novel C-7 quinolyl-substituted enantiomers of ofloxacin were used to determine the stereospecificity of topoisomerase II for the C-11 methyl group in tricyclic quinolones. In all cases, the S isomer was the most active compound against the eukaryotic enzyme. It was approximately 2.2-fold...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Froelich-Ammon, S J, McGuirk, P R, Gootz, T D, Jefson, M R, Osheroff, N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187729/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8388196/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.4.646
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