Novel 1-8-bridged chiral quinolones with activity against topoisomerase II: stereospecificity of the eukaryotic enzyme.
A series of novel C-7 quinolyl-substituted enantiomers of ofloxacin were used to determine the stereospecificity of topoisomerase II for the C-11 methyl group in tricyclic quinolones. In all cases, the S isomer was the most active compound against the eukaryotic enzyme. It was approximately 2.2-fold...
שמור ב:
| הוצא לאור ב: | Antimicrob Agents Chemother |
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| Principais autores: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Microbiology (ASM)
1993
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187729/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8388196/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.4.646 |
| תגים: |
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