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Real-time footprinting of DNA in the first kinetically significant intermediate in open complex formation by Escherichia coli RNA polymerase

The architecture of cellular RNA polymerases (RNAPs) dictates that transcription can begin only after promoter DNA bends into a deep channel and the start site nucleotide (+1) binds in the active site located on the channel floor. Formation of this transcriptionally competent “open” complex (RP(o))...

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Bibliografiske detaljer
Main Authors: Davis, Caroline A., Bingman, Craig A., Landick, Robert, Record, M. Thomas, Saecker, Ruth M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876533/
https://ncbi.nlm.nih.gov/pubmed/17470797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609888104
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