A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex.

Binding of the quinolone drug norfloxacin to gyrase and DNA has been investigated. We have detected binding to gyrase-DNA complex but find no significant binding to either gyrase or DNA alone. Enzyme containing gyrase A protein with the mutation Ser-83 to Trp (conferring quinolone resistance) showed...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Willmott, C J, Maxwell, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8381633/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.1.126
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