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Interaction between DNA Gyrase and Quinolones: Effects of Alanine Mutations at GyrA Subunit Residues Ser(83) and Asp(87)

DNA gyrase is a target of quinolone antibacterial agents, but the molecular details of the quinolone-gyrase interaction are not clear. Quinolone resistance mutations frequently occur at residues Ser(83) and Asp(87) of the gyrase A subunit, suggesting that these residues are involved in drug binding....

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Detalhes bibliográficos
Main Authors: Barnard, Faye M., Maxwell, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90591/
https://ncbi.nlm.nih.gov/pubmed/11408214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.7.1994-2000.2001
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