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Interaction between DNA Gyrase and Quinolones: Effects of Alanine Mutations at GyrA Subunit Residues Ser(83) and Asp(87)

DNA gyrase is a target of quinolone antibacterial agents, but the molecular details of the quinolone-gyrase interaction are not clear. Quinolone resistance mutations frequently occur at residues Ser(83) and Asp(87) of the gyrase A subunit, suggesting that these residues are involved in drug binding....

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Barnard, Faye M., Maxwell, Anthony
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90591/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11408214/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.7.1994-2000.2001
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