A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex.
Binding of the quinolone drug norfloxacin to gyrase and DNA has been investigated. We have detected binding to gyrase-DNA complex but find no significant binding to either gyrase or DNA alone. Enzyme containing gyrase A protein with the mutation Ser-83 to Trp (conferring quinolone resistance) showed...
সংরক্ষণ করুন:
| প্রকাশিত: | Antimicrob Agents Chemother |
|---|---|
| প্রধান লেখক: | , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
American Society for Microbiology (ASM)
1993
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8381633/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.1.126 |
| ট্যাগগুলো: |
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