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CD44 is required for two consecutive steps in HGF/c-Met signaling

The tyrosine kinase receptor c-Met and its ligand HGF/SF, ezrin, and splice variants of CD44 have independently been identified as tumor metastasis-associated proteins. We now show that these proteins cooperate. A CD44 isoform containing variant exon v6 sequences is strictly required for c-Met activ...

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Published in:Genes Dev
Main Authors: Orian-Rousseau, Véronique, Chen, Linfeng, Sleeman, Jonathan P., Herrlich, Peter, Ponta, Helmut
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2002
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Research Paper
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187488/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12464636/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.242602
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