Increased amyloidogenic secretion in cerebellar granule cells undergoing apoptosis

Some clues suggest that neuronal damage induces a secondary change of amyloid β protein (Aβ) metabolism. We investigated this possibility by analyzing the secretion of Aβ and processing of its precursor protein (amyloid precursor protein, APP) in an in vitro model of neuronal apoptosis. Primary cult...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Galli, Cinzia, Piccini, Alessandra, Ciotti, Maria Teresa, Castellani, Loriana, Calissano, Pietro, Zaccheo, Damiano, Tabaton, Massimo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9448317/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.3.1247
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