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Coinjection with CpG-Containing Immunostimulatory Oligodeoxynucleotides Reduces the Pathogenicity of a Live Vaccine against Cutaneous Leishmaniasis but Maintains Its Potency and Durability

The inoculation of live, nonattenuated Leishmania major to produce a lesion in a selected site that heals, referred to as leishmanization, is to date the only vaccine against leishmaniasis that has proven to be effective in humans. Its use has been restricted or abandoned entirely, however, due to s...

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Detalhes bibliográficos
Publicado no:Infect Immun
Principais autores: Mendez, Susana, Tabbara, Khaled, Belkaid, Yasmine, Bertholet, Sylvie, Verthelyi, Daniela, Klinman, Dennis, Seder, Robert A., Sacks, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187328/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12933855/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.9.5121-5129.2003
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