Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparallel Guanine-Quadruplex Structural Scaffold

Guanine-quadruplex-based CpG oligodeoxynucleotides (G4 CpG ODNs) have been developed as potent immunostimulatory agents with reduced sensitivity to nucleases. We designed new monomeric G4 ODNs with an antiparallel topology using antiparallel type duplex/G4 ODNs as robust scaffolds, and we characteri...

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Detalhes bibliográficos

Principais autores:	Fika Ayu Safitri, Anh Thi Tram Tu, Kazuaki Hoshi, Miwako Shobo, Dandan Zhao, Arief Budi Witarto, Sony Heru Sumarsono, Ernawati Arifin Giri-Rachman, Kaori Tsukakoshi, Kazunori Ikebukuro, Tomohiko Yamazaki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-11-01
Colecção:	Biomolecules
Assuntos:	guanine quadruplex high-order structure monomeric immunostimulatory activity adjuvant
Acesso em linha:	https://www.mdpi.com/2218-273X/11/11/1617
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