Non-Modified CpG Oligodeoxynucleotide Forming Guanine-Quadruplex Structure Complexes with ε-Poly-_L-Lysine Induce Antibody Production as Vaccine Adjuvants

Unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides (CpG ODNs) induce inflammatory cytokines and type I interferons (IFNs) to activate the immune system. To apply CpG ODNs as vaccine adjuvants, the cellular uptake and stability of phosphodiester-based, non-modified ODNs require further i...

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主要な著者:	Dandan Zhao, Anh Thi Tram Tu, Miwako Shobo, Nguyen Bui Thao Le, Chiaki Yoshikawa, Kazuhisa Sugai, Yoji Hakamata, Tomohiko Yamazaki
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2022-12-01
シリーズ:	Biomolecules
主題:	guanine quadruplex CpG oligodeoxynucleotides ε-poly-<sub>L</sub>-lysine immune stimulation cytokine induction
オンライン･アクセス:	https://www.mdpi.com/2218-273X/12/12/1868
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