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SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK

ITK (IL-2-inducible T cell kinase), a Tec family protein tyrosine kinase (PTK), is one of three PTKs required for T cell antigen receptor (TCR)-induced activation of phospholipase C-γ1 (PLC-γ1). Like Src and Abl family PTKs, ITK adopts an inactive, “closed” conformation, and its conversion to the ac...

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Bibliografiske detaljer
Main Authors: Bogin, Yaron, Ainey, Carmit, Beach, Dvora, Yablonski, Deborah
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871838/
https://ncbi.nlm.nih.gov/pubmed/17420479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609771104
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