Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

PPARγ is required for fat cell development and is the molecular target of antidiabetic thiazolidinediones (TZDs), which exert insulin-sensitizing effects in adipose tissue, skeletal muscle, and liver. Unexpectedly, we found that inactivation of PPARγ in macrophages results in the development of sign...

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Bibliografiset tiedot
Päätekijät: Hevener, Andrea L., Olefsky, Jerrold M., Reichart, Donna, Nguyen, M.T. Audrey, Bandyopadyhay, Gautam, Leung, Ho-Yin, Watt, Matthew J., Benner, Chris, Febbraio, Mark A., Nguyen, Anh-Khoi, Folian, Brian, Subramaniam, Shankar, Gonzalez, Frank J., Glass, Christopher K., Ricote, Mercedes
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2007
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868788/
https://ncbi.nlm.nih.gov/pubmed/17525798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31561
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