Design and synthesis of a novel quinoline thiazolidinedione hybrid as a potential antidiabetic PPARγ modulator

Abstract Peroxisome proliferator-activated receptor γ (PPARγ) remains a critical target for antidiabetic drug development due to its role in glucose and lipid metabolism. However, the adverse effects associated with full agonists of the thiazolidinedione (TZD) class, such as weight gain and hepatoto...

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Detalhes bibliográficos
Main Authors: Ayman M. Ibrahim, Mai E. Shoman, Radwa Taher Mohie el-dien, Entesar Ali Saber, Mahmoud Abdelnaser, Sherif A. Maher, Alaa M. Hayallah, Mahmoud Abdul-Aziz El-Rehany, Gamal El-Din A. Abuo-Rahma
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-06-01
Colecção:Scientific Reports
Assuntos:
Quinoline
Thiazolidinedione
PPARγ
Antidiabetic
SPPARMs
Acesso em linha:https://doi.org/10.1038/s41598-025-03387-9
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