Design and synthesis of a novel quinoline thiazolidinedione hybrid as a potential antidiabetic PPARγ modulator

Abstract Peroxisome proliferator-activated receptor γ (PPARγ) remains a critical target for antidiabetic drug development due to its role in glucose and lipid metabolism. However, the adverse effects associated with full agonists of the thiazolidinedione (TZD) class, such as weight gain and hepatoto...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Ayman M. Ibrahim, Mai E. Shoman, Radwa Taher Mohie el-dien, Entesar Ali Saber, Mahmoud Abdelnaser, Sherif A. Maher, Alaa M. Hayallah, Mahmoud Abdul-Aziz El-Rehany, Gamal El-Din A. Abuo-Rahma
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-06-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Quinoline Thiazolidinedione PPARγ Antidiabetic SPPARMs
Online-Zugang:	https://doi.org/10.1038/s41598-025-03387-9
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