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Thiazolidinedione-Conjugated Lupeol Derivatives as Potent Anticancer Agents Through a Mitochondria-Mediated Apoptotic Pathway

To improve the potential of lupeol against cancer cells, a privileged structure, thiazolidinedione, was introduced into its C-3 hydroxy group with ester, piperazine-carbamate, or ethylenediamine as a linker, and three series of thiazolidinedione-conjugated compounds (<b>6a</b>–<b>i</b>, <b>9a</b>–<b...

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Principais autores: Siqi Deng, Yinxu Zhao, Xiaoshan Guo, Xian Hong, Gang Li, Yuchun Wang, Qingyi Li, Ming Bu, Ming Wang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-10-01
Serier:Molecules
Fag:
triterpenoid
lupeol
thiazolidinedione
hybrids
antitumor
apoptotic
Online adgang:https://www.mdpi.com/1420-3049/29/20/4957
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