Brain PPARγ Promotes Obesity and is Required for the Insulin–Sensitizing Effect of Thiazolidinediones

In adipose, muscle, liver and macrophages, signaling by the nuclear receptor PPARγ is a determinant of insulin sensitivity and this receptor mediates the insulin–sensitizing effects of thioazolidinediones (TZDs)(1-4). Since PPARγ is also expressed in neurons(5), we generated mice with neuron–specifi...

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Autores principales: Lu, Min, Sarruf, David A., Talukdar, Saswata, Sharma, Shweta, Li, Pingping, Bandyopadhyay, Gautam, Nalbandian, Sarah, Fan, WuQiang, Gayen, Jiaur R., Mahata, Sushil K., Webster, Nicholas J., Schwartz, Michael W., Olefsky, Jerrold M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380629/
https://ncbi.nlm.nih.gov/pubmed/21532596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2332
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