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Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention

Infection with dengue virus (DENV) or any other flavivirus induces cross-reactive, but weakly neutralizing or nonneutralizing, antibodies that recognize epitopes involving the fusion peptide in the envelope glycoprotein. Humanized mAb IgG 1A5, derived from a chimpanzee, shares properties of cross-re...

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Detalhes bibliográficos
Main Authors: Goncalvez, Ana P., Engle, Ronald E., St. Claire, Marisa, Purcell, Robert H., Lai, Ching-Juh
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868655/
https://ncbi.nlm.nih.gov/pubmed/17517625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703498104
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