Intraneuronal Aβ42 Accumulation in Human Brain

Alzheimer’s disease (AD) is characterized by the deposition of senile plaques (SPs) and neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated β-amyloid (Aβ) 40/42(43) peptides. Evidence implicates a central role for Aβ in the pathophysiology of AD. Mutations in β...

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Autori principali: Gouras, Gunnar K., Tsai, Julia, Naslund, Jan, Vincent, Bruno, Edgar, Mark, Checler, Frederic, Greenfield, Jeffrey P., Haroutunian, Vahram, Buxbaum, Joseph D., Xu, Huaxi, Greengard, Paul, Relkin, Norman R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2000
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Short Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868613/
https://ncbi.nlm.nih.gov/pubmed/10623648
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