Intraneuronal Aβ42 Accumulation in Human Brain

Alzheimer’s disease (AD) is characterized by the deposition of senile plaques (SPs) and neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated β-amyloid (Aβ) 40/42(43) peptides. Evidence implicates a central role for Aβ in the pathophysiology of AD. Mutations in β...

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Bibliographische Detailangaben
Hauptverfasser: Gouras, Gunnar K., Tsai, Julia, Naslund, Jan, Vincent, Bruno, Edgar, Mark, Checler, Frederic, Greenfield, Jeffrey P., Haroutunian, Vahram, Buxbaum, Joseph D., Xu, Huaxi, Greengard, Paul, Relkin, Norman R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2000
Schlagworte:
Short Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868613/
https://ncbi.nlm.nih.gov/pubmed/10623648
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