Vertebrate POLQ and POLβ Cooperate in Base Excision Repair of Oxidative DNA Damage

Base excision repair (BER) plays an essential role in protecting cells from mutagenic base damage caused by oxidative stress, hydrolysis, and environmental factors. POLQ is a DNA polymerase, which appears to be involved in translesion DNA synthesis (TLS) past base damage. We disrupted POLQ, and its...

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Hlavní autoři: Yoshimura, Michio, Kohzaki, Masaoki, Nakamura, Jun, Asagoshi, Kenjiro, Sonoda, Eiichiro, Hou, Esther, Prasad, Rajendra, Wilson, Samuel H., Tano, Keizo, Yasui, Akira, Lan, Li, Seki, Mineaki, Wood, Richard D., Arakawa, Hiroshi, Buerstedde, Jean-Marie, Hochegger, Helfrid, Okada, Takashi, Hiraoka, Masahiro, Takeda, Shunichi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868411/
https://ncbi.nlm.nih.gov/pubmed/17018297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.07.032
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