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An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells
In vertebrates Cdk1 is required to initiate mitosis; however, any functionality of this kinase during S phase remains unclear. To investigate this, we generated chicken DT40 mutants, in which an analog-sensitive mutant cdk1 as replaces the endogenous Cdk1, allowing us to specifically inactivate Cdk1...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064445/ https://ncbi.nlm.nih.gov/pubmed/17635936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200702034 |
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