Antigenic and Immunogenic Study of Membrane-Proximal External Region-Grafted gp120 Antigens by a DNA Prime-Protein Boost Immunization Strategy

The membrane-proximal external region (MPER) of human immunodeficiency virus type 1 (HIV-1) gp41 is a target of broadly neutralizing monoclonal antibodies (MAbs) 2F5, 4E10, and Z13. Here we engrafted the MPER into the V1/2 region of HIV-1 gp120 to investigate the ability of the engineered antigens t...

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Bibliografiska uppgifter
Huvudupphovsmän: Law, Mansun, Cardoso, Rosa M. F., Wilson, Ian A., Burton, Dennis R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2007
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866136/
https://ncbi.nlm.nih.gov/pubmed/17267498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02536-06
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