A Glycoconjugate Antigen Based on the Recognition Motif of a Broadly Neutralizing Human Immunodeficiency Virus Antibody, 2G12, Is Immunogenic but Elicits Antibodies Unable To Bind to the Self Glycans of gp120

The glycan shield of human immunodeficiency virus type 1 (HIV-1) gp120 contributes to viral evasion from humoral immune responses. However, the shield is recognized by the HIV-1 broadly neutralizing antibody (Ab), 2G12, at a relatively conserved cluster of oligomannose glycans. The discovery of 2G12...

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Detalhes bibliográficos
Main Authors: Astronomo, Rena D., Lee, Hing-Ken, Scanlan, Christopher N., Pantophlet, Ralph, Huang, Cheng-Yuan, Wilson, Ian A., Blixt, Ola, Dwek, Raymond A., Wong, Chi-Huey, Burton, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447108/
https://ncbi.nlm.nih.gov/pubmed/18434393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00293-08
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