The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2G12 Recognizes a Cluster of α1→2 Mannose Residues on the Outer Face of gp120

2G12 is a broadly neutralizing human monoclonal antibody against human immunodeficiency virus type-1 (HIV-1) that has previously been shown to bind to a carbohydrate-dependent epitope on gp120. Here, site-directed mutagenesis and carbohydrate analysis were used to define further the 2G12 epitope. Ex...

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Bibliographic Details
Main Authors: Scanlan, Christopher N., Pantophlet, Ralph, Wormald, Mark R., Ollmann Saphire, Erica, Stanfield, Robyn, Wilson, Ian A., Katinger, Hermann, Dwek, Raymond A., Rudd, Pauline M., Burton, Dennis R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC136327/
https://ncbi.nlm.nih.gov/pubmed/12072529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.14.7306-7321.2002
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