Cytosolic Prion Protein Toxicity Is Independent of Cellular Prion Protein Expression and Prion Propagation

Prion diseases are transmissible neurodegenerative diseases caused by a conformational isoform of the prion protein (PrP), a host-encoded cell surface sialoglycoprotein. Recent evidence suggests a cytosolic fraction of PrP (cyPrP) functions either as an initiating factor or toxic element of prion di...

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Bibliographic Details
Main Authors: Norstrom, Eric M., Ciaccio, Mark F., Rassbach, Benjamin, Wollmann, Robert, Mastrianni, James A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866012/
https://ncbi.nlm.nih.gov/pubmed/17182694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02157-06
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