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The Charge Structure of Helix 1 in the Prion Protein Regulates Conversion to Pathogenic PrP(Sc)
The prion diseases are transmissible neurodegenerative disorders linked to a pathogenic conformer (PrP(Sc)) of the normal prion protein (PrP(C)). Accumulation of PrP(Sc) occurs via a poorly defined process in which PrP(Sc) complexes with and converts endogenous PrP(C) to nascent PrP(Sc). Recent expe...
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| Hoofdauteurs: | , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Microbiology
2006
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1563859/ https://ncbi.nlm.nih.gov/pubmed/16912302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00366-06 |
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