Caricamento...
Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context
The environmental carcinogen benzo[a]pyrene (BP) is metabolized to reactive diol epoxides that bind to cellular DNA by predominantly forming N(2)-guanine adducts (G*). Mutation hotspots for these adducts are frequently found in 5′- ··· GG ··· dinucleotide sequences, but their origins are poorly unde...
Salvato in:
Autori principali: | , , , , , , , , |
---|---|
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
Oxford University Press
2007
|
Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1865068/ https://ncbi.nlm.nih.gov/pubmed/17287290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm022 |
Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|