Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context

The environmental carcinogen benzo[a]pyrene (BP) is metabolized to reactive diol epoxides that bind to cellular DNA by predominantly forming N(2)-guanine adducts (G*). Mutation hotspots for these adducts are frequently found in 5′- ··· GG ··· dinucleotide sequences, but their origins are poorly unde...

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Hlavní autoři: Rodríguez, Fabián A., Cai, Yuqin, Lin, Chin, Tang, Yijin, Kolbanovskiy, Alexander, Amin, Shantu, Patel, Dinshaw J., Broyde, Suse, Geacintov, Nicholas E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2007
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865068/
https://ncbi.nlm.nih.gov/pubmed/17287290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm022
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