Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III

Single gene mutations in β integrins can account for functional defects of individual cells of the hematopoietic system. In humans, mutations in β(2) integrin lead to leukocyte adhesion deficiency (LAD) syndrome and mutations in β(3) integrin cause the bleeding disorder Glanzmann thrombasthenia. How...

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Main Authors: Bergmeier, Wolfgang, Goerge, Tobias, Wang, Hong-Wei, Crittenden, Jill R., Baldwin, Andrew C.W., Cifuni, Stephen M., Housman, David E., Graybiel, Ann M., Wagner, Denisa D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865026/
https://ncbi.nlm.nih.gov/pubmed/17492052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30575
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