CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease

Huntingtin protein (Htt) is ubiquitously expressed, yet Huntington's disease (HD), a fatal neurologic disorder produced by expansion of an Htt polyglutamine tract, is characterized by neurodegeneration that occurs primarily in the striatum and cerebral cortex. Such discrepancies between sites o...

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Autors principals: Crittenden, Jill R., Dunn, Denise E., Merali, Farhan I., Woodman, Ben, Yim, Michael, Borkowska, Anna E., Frosch, Matthew P., Bates, Gillian P., Housman, David E., Lo, Donald C., Graybiel, Ann M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850620/
https://ncbi.nlm.nih.gov/pubmed/20147317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq055
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