Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy

Voluntary movement difficulties in Parkinson's disease are initially relieved by l-DOPA therapy, but with disease progression, the repeated l-DOPA treatments can produce debilitating motor abnormalities known as l-DOPA-induced dyskinesias. We show here that 2 striatum-enriched regulators of the...

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Hlavní autoři: Crittenden, Jill R., Cantuti-Castelvetri, Ippolita, Saka, Esen, Keller-McGandy, Christine E., Hernandez, Ledia F., Kett, Lauren R., Young, Anne B., Standaert, David G., Graybiel, Ann M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650361/
https://ncbi.nlm.nih.gov/pubmed/19171906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812822106
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