Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis

Chemotaxis and integrin activation are essential processes for neutrophil transmigration in response to injury. CalDAG-GEFI plays a key role in the activation of β1, β2, and β3 integrins in platelets and neutrophils by exchanging a GDP for a GTP on Rap1. Here, we explored the role of CalDAG-GEFI and...

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Detalhes bibliográficos
Main Authors: Carbo, Carla, Duerschmied, Daniel, Goerge, Tobias, Hattori, Hidenori, Sakai, Jiro, Cifuni, Stephen M., White, Gilbert C., Chrzanowska-Wodnicka, Magdalena, Luo, Hongbo R., Wagner, Denisa D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Society for Leukocyte Biology 2010
Assuntos:
Inflammation, Extracellular Mediators, & Effector Molecules
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908939/
https://ncbi.nlm.nih.gov/pubmed/20413728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0110049
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