CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin αIIbβ3 in platelets

Second messenger-mediated inside-out activation of integrin αIIbβ3 is a key step in platelet aggregation. We recently showed strongly impaired but not absent αIIbβ3-mediated aggregation of CalDAG-GEFI–deficient platelets activated with various agonists. Here we further evaluated the roles of CalDAG-...

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Autores principales: Cifuni, Stephen M., Wagner, Denisa D., Bergmeier, Wolfgang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2008
Materias:
Hemostasis, Thrombosis, and Vascular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518880/
https://ncbi.nlm.nih.gov/pubmed/18544684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-139733
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