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Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate

Polo-like kinase-1 (Plk1) phosphorylates a number of mitotic substrates, but the diversity of Plk1-dependent processes suggests the existence of additional targets. Plk1 contains a specialized phosphoserine–threonine binding domain, the Polo-box domain (PBD), postulated to target the kinase to its s...

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Detalhes bibliográficos
Main Authors: Lowery, Drew M, Clauser, Karl R, Hjerrild, Majbrit, Lim, Dan, Alexander, Jes, Kishi, Kazuhiro, Ong, Shao-En, Gammeltoft, Steen, Carr, Steven A, Yaffe, Michael B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864981/
https://ncbi.nlm.nih.gov/pubmed/17446864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601683
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