Essential Roles of the CC Chemokine Ligand 3-CC Chemokine Receptor 5 Axis in Bleomycin-Induced Pulmonary Fibrosis through Regulation of Macrophage and Fibrocyte Infiltration

We investigated the pathogenic roles of CC chemokine ligand (CCL)3 and its receptors, CC chemokine receptor (CCR)1 and CCR5, in bleomycin (BLM)-induced pulmonary fibrosis (PF). An intratracheal injection of BLM into wild-type (WT) mice caused a massive infiltration of granulocytes and macrophages, f...

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Bibliographic Details
Main Authors: Ishida, Yuko, Kimura, Akihiko, Kondo, Toshikazu, Hayashi, Takahito, Ueno, Masaya, Takakura, Nobuyuki, Matsushima, Kouji, Mukaida, Naofumi
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2007
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Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864886/
https://ncbi.nlm.nih.gov/pubmed/17322370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.051213
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