The Absence of Interleukin-6 Enhanced Arsenite-Induced Renal Injury by Promoting Autophagy of Tubular Epithelial Cells with Aberrant Extracellular Signal-Regulated Kinase Activation

Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by 3-methyladenine or Atg7 knockdown. The inhibition of the IL-6/signal transducer...

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Main Authors: Kimura, Akihiko, Ishida, Yuko, Wada, Takashi, Hisaoka, Tomoko, Morikawa, Yoshihiro, Sugaya, Takeshi, Mukaida, Naofumi, Kondo, Toshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797868/
https://ncbi.nlm.nih.gov/pubmed/20008137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090146
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