Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration

The potential role of macrophages in pulmonary fibrosis (PF) prompted us to evaluate the roles of CX3CR1, a chemokine receptor abundantly expressed in macrophages during bleomycin (BLM)-induced PF. Intratracheal BLM injection induced infiltration of leukocytes such as macrophages into the lungs, whi...

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Udgivet i:Sci Rep
Main Authors: Ishida, Yuko, Kimura, Akihiko, Nosaka, Mizuho, Kuninaka, Yumi, Hemmi, Hiroaki, Sasaki, Izumi, Kaisho, Tsuneyasu, Mukaida, Naofumi, Kondo, Toshikazu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714949/
https://ncbi.nlm.nih.gov/pubmed/29203799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17007-8
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