Smad3 allostery links TGF-β receptor kinase activation to transcriptional control

Smad3 transduces the signals of TGF-βs, coupling transmembrane receptor kinase activation to transcriptional control. The membrane-associated molecule SARA (Smad Anchor for Receptor Activation) recruits Smad3 for phosphorylation by the receptor kinase. Upon phosphorylation, Smad3 dissociates from SA...

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Autors principals: Qin, Bin Y., Lam, Suvana S., Correia, John J., Lin, Kai
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2002
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC186427/
https://ncbi.nlm.nih.gov/pubmed/12154125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1002002
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