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Smad3 allostery links TGF-β receptor kinase activation to transcriptional control
Smad3 transduces the signals of TGF-βs, coupling transmembrane receptor kinase activation to transcriptional control. The membrane-associated molecule SARA (Smad Anchor for Receptor Activation) recruits Smad3 for phosphorylation by the receptor kinase. Upon phosphorylation, Smad3 dissociates from SA...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC186427/ https://ncbi.nlm.nih.gov/pubmed/12154125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1002002 |
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