The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation
Stably integrated transgenes flanked by the chicken β-globin HS4 insulator are protected against chromosomal position effects and gradual extinction of expression during long-term propagation in culture. To investigate the mechanism of action of this insulator, we used bisulfite genomic sequencing t...
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| Опубліковано в:: | Genes Dev |
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| Автори: | , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Cold Spring Harbor Laboratory Press
2002
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186352/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12080092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.988502 |
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