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The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation
Stably integrated transgenes flanked by the chicken β-globin HS4 insulator are protected against chromosomal position effects and gradual extinction of expression during long-term propagation in culture. To investigate the mechanism of action of this insulator, we used bisulfite genomic sequencing t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC186352/ https://ncbi.nlm.nih.gov/pubmed/12080092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.988502 |
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